SUCNR1
Gene Information
- Official Symbol: SUCNR1
- Official Name: succinate receptor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 56670
- UniProt: Q9BXA5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for succinate. {ECO:0000269|PubMed:15141213}.
Pfam Domains GO Terms
Pfam Domains
| 7tm 1 |
GO Terms
| regulation of angiotensin metabolic process |
| renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure |
| renin secretion into blood stream |
| macrophage activation involved in immune response |
| interleukin-1 beta production |
| regulation of systemic arterial blood pressure by circulatory renin-angiotensin |
| interleukin-1 production |
| regulation of systemic arterial blood pressure by renin-angiotensin |
| renal system process involved in regulation of systemic arterial blood pressure |
| regulation of systemic arterial blood pressure by hormone |
| regulation of systemic arterial blood pressure mediated by a chemical signal |
| endocrine process |
| macrophage activation |
| regulation of systemic arterial blood pressure |
| renal system process |
| positive regulation of chemotaxis |
| positive regulation of inflammatory response |
| cytokine production |
| response to calcium ion |
| protein secretion |
| establishment of protein localization to extracellular region |
| protein localization to extracellular region |
| peptide secretion |
| regulation of blood pressure |
| glucose homeostasis |
| carbohydrate homeostasis |
| regulation of chemotaxis |
| regulation of inflammatory response |
| response to metal ion |
| blood circulation |
| circulatory system process |
| positive regulation of defense response |
| myeloid cell activation involved in immune response |
| response to inorganic substance |
| positive regulation of locomotion |
| myeloid leukocyte activation |
| positive regulation of response to external stimulus |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| G protein-coupled receptor activity |
| regulation of defense response |
| leukocyte activation |
| regulation of locomotion |
| secretion by cell |
| export from cell |
| cell activation |
| immune effector process |
| regulation of response to external stimulus |
| chemical homeostasis |
| secretion |
| G protein-coupled receptor signaling pathway |
| regulation of response to stress |
| protein transport |
| peptide transport |
| amide transport |
| establishment of protein localization |
| homeostatic process |
| nitrogen compound transport |
| immune response |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| NN-Diethyl-meta-toluamide 500μM R08 exp438 | 1.74 |
| Ibrutinib 10μM R08 exp442 | 2.14 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18150
- Expression level (log2 read counts): -3.28
Expression Distribution
SUCNR1 Expression in NALM6 Cells: -3.28
