Pfam Domains GO Terms
| PDZ |
| positive regulation of Rho protein signal transduction |
| sarcomere organization |
| positive regulation of stress fiber assembly |
| positive regulation of actin filament bundle assembly |
| positive regulation of Ras protein signal transduction |
| myofibril assembly |
| positive regulation of small GTPase mediated signal transduction |
| regulation of stress fiber assembly |
| regulation of actomyosin structure organization |
| regulation of actin filament bundle assembly |
| cellular component assembly involved in morphogenesis |
| actomyosin structure organization |
| Z disc |
| striated muscle cell development |
| regulation of Rho protein signal transduction |
| muscle cell development |
| positive regulation of supramolecular fiber organization |
| striated muscle cell differentiation |
| actin cytoskeleton |
| positive regulation of cytoskeleton organization |
| regulation of Ras protein signal transduction |
| muscle cell differentiation |
| heart morphogenesis |
| regulation of actin filament organization |
| actin binding |
| regulation of actin cytoskeleton organization |
| regulation of small GTPase mediated signal transduction |
| regulation of supramolecular fiber organization |
| regulation of actin filament-based process |
| nuclear speck |
| supramolecular fiber organization |
| muscle structure development |
| actin cytoskeleton organization |
| positive regulation of cellular component biogenesis |
| heart development |
| regulation of cytoskeleton organization |
| cell junction |
| actin filament-based process |
| positive regulation of organelle organization |
| organelle assembly |
| cellular component morphogenesis |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| positive regulation of intracellular signal transduction |
| cytoskeleton organization |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| cell development |
| positive regulation of signal transduction |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| IWR1 50μM R08 exp495 | 1.75 |
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.414 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution