TAC1
Gene Information
- Official Symbol: TAC1
- Official Name: tachykinin precursor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6863
- UniProt: P20366
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| positive regulation of corticosterone secretion |
| positive regulation of saliva secretion |
| substance P receptor binding |
| regulation of corticosterone secretion |
| positive regulation of synaptic transmission, cholinergic |
| positive regulation of glucocorticoid secretion |
| regulation of synaptic transmission, cholinergic |
| regulation of saliva secretion |
| tachykinin receptor signaling pathway |
| positive regulation of corticosteroid hormone secretion |
| positive regulation of action potential |
| positive regulation of digestive system process |
| positive regulation of steroid hormone secretion |
| regulation of glucocorticoid secretion |
| negative regulation of heart rate |
| insemination |
| positive regulation of synaptic transmission, GABAergic |
| positive regulation of renal sodium excretion |
| copulation |
| regulation of corticosteroid hormone secretion |
| regulation of steroid hormone secretion |
| regulation of renal sodium excretion |
| regulation of excretion |
| negative regulation of heart contraction |
| positive regulation of acute inflammatory response |
| response to pain |
| regulation of synaptic transmission, GABAergic |
| long-term memory |
| mating |
| response to morphine |
| negative regulation of blood circulation |
| response to isoquinoline alkaloid |
| regulation of renal system process |
| regulation of digestive system process |
| regulation of endocrine process |
| regulation of acute inflammatory response |
| cellular response to nerve growth factor stimulus |
| regulation of action potential |
| positive regulation of stress fiber assembly |
| response to nerve growth factor |
| positive regulation of actin filament bundle assembly |
| positive regulation of lipid transport |
| multicellular organismal response to stress |
| sensory perception of pain |
| associative learning |
| response to anesthetic |
| regulation of stress fiber assembly |
| positive regulation of lipid localization |
| positive regulation of ossification |
| regulation of actomyosin structure organization |
| regulation of actin filament bundle assembly |
| regulation of heart rate |
| neuropeptide signaling pathway |
| regulation of lipid transport |
| response to alkaloid |
| memory |
| detection of abiotic stimulus |
| positive regulation of hormone secretion |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| positive regulation of leukocyte proliferation |
| regulation of lipid localization |
| positive regulation of inflammatory response |
| positive regulation of epithelial cell migration |
| learning |
| positive regulation of synaptic transmission |
| regulation of blood pressure |
| response to ammonium ion |
| regulation of ossification |
| positive regulation of supramolecular fiber organization |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| multi-multicellular organism process |
| regulation of epithelial cell migration |
| positive regulation of cytoskeleton organization |
| regulation of leukocyte proliferation |
| regulation of heart contraction |
| learning or memory |
| regulation of actin filament organization |
| regulation of hormone secretion |
| positive regulation of cytosolic calcium ion concentration |
| regulation of blood circulation |
| axon |
| cognition |
| response to xenobiotic stimulus |
| response to lipopolysaccharide |
| response to molecule of bacterial origin |
| regulation of cytosolic calcium ion concentration |
| regulation of inflammatory response |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| positive regulation of lymphocyte activation |
| neuronal cell body |
| regulation of actin filament-based process |
| blood circulation |
| circulatory system process |
| positive regulation of secretion by cell |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| chemical synaptic transmission |
| anterograde trans-synaptic signaling |
| regulation of membrane potential |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| calcium ion homeostasis |
| synaptic signaling |
| cellular divalent inorganic cation homeostasis |
| positive regulation of defense response |
| divalent inorganic cation homeostasis |
| regulation of body fluid levels |
| inflammatory response |
| positive regulation of cell migration |
| cellular response to growth factor stimulus |
| regulation of lymphocyte activation |
| positive regulation of cellular component biogenesis |
| positive regulation of cell motility |
| response to growth factor |
| regulation of hormone levels |
| positive regulation of cellular component movement |
| regulation of cytoskeleton organization |
| positive regulation of locomotion |
| cellular metal ion homeostasis |
| behavior |
| regulation of system process |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| positive regulation of organelle organization |
| metal ion homeostasis |
| cellular cation homeostasis |
| regulation of cell activation |
| cellular ion homeostasis |
| response to bacterium |
| detection of stimulus |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| regulation of secretion by cell |
| regulation of defense response |
| ion homeostasis |
| regulation of secretion |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| regulation of cell migration |
| response to lipid |
| cellular homeostasis |
| response to hormone |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| regulation of cellular component biogenesis |
| sensory perception |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| multi-organism reproductive process |
| response to organonitrogen compound |
| response to drug |
| response to nitrogen compound |
| regulation of response to external stimulus |
| chemical homeostasis |
| cell-cell signaling |
| positive regulation of immune system process |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| defense response |
| nervous system process |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| regulation of response to stress |
| response to oxygen-containing compound |
| extracellular space |
| regulation of cell population proliferation |
| homeostatic process |
| regulation of immune system process |
| positive regulation of multicellular organismal process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of transport |
| extracellular region |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Hippuristanol 0.12μM R08 exp489 no dilution day6 | -1.73 |
| Taxol 0.004μM R03 exp103 | 1.97 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17345
- Expression level (log2 read counts): -7.68
Expression Distribution
TAC1 Expression in NALM6 Cells: -7.68
