TCF20
Gene Information
- Official Symbol: TCF20
- Official Name: transcription factor 20
- Aliases and Previous Symbols: N/A
- Entrez ID: 6942
- UniProt: Q9UGU0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a transcription factor that recognizes the platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 promoter. The encoded protein is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Mutations in this gene are associated with autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
- UniProt Summary: Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 10703
- Expression level (log2 read counts): 5.96
TCF20 Expression in NALM6 Cells: 5.96
