TIRAP
Gene Information
- Official Symbol: TIRAP
- Official Name: TIR domain containing adaptor protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 114609
- UniProt: P58753
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008].
- UniProt Summary: Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6. {ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19509286}.
Pfam Domains GO Terms
Pfam Domains
| TIR |
GO Terms
| positive regulation of interleukin-15 production |
| TIRAP-dependent toll-like receptor 4 signaling pathway |
| regulation of interleukin-15 production |
| TIRAP-dependent toll-like receptor signaling pathway |
| regulation of chemokine (C-X-C motif) ligand 1 production |
| positive regulation of chemokine (C-X-C motif) ligand 1 production |
| Toll-like receptor 2 binding |
| Toll-like receptor 4 binding |
| positive regulation of toll-like receptor 2 signaling pathway |
| cellular response to bacterial lipoprotein |
| cellular response to bacterial lipopeptide |
| response to bacterial lipopeptide |
| response to bacterial lipoprotein |
| positive regulation of toll-like receptor 3 signaling pathway |
| positive regulation of toll-like receptor 4 signaling pathway |
| positive regulation of chemokine (C-X-C motif) ligand 2 production |
| regulation of toll-like receptor 3 signaling pathway |
| cellular response to lipoteichoic acid |
| response to lipoteichoic acid |
| regulation of toll-like receptor 2 signaling pathway |
| positive regulation of protein homodimerization activity |
| regulation of chemokine (C-X-C motif) ligand 2 production |
| positive regulation of interleukin-6 biosynthetic process |
| activation of NF-kappaB-inducing kinase activity |
| 3-UTR-mediated mRNA stabilization |
| toll-like receptor 4 signaling pathway |
| regulation of toll-like receptor 4 signaling pathway |
| regulation of protein homodimerization activity |
| positive regulation of toll-like receptor signaling pathway |
| regulation of interleukin-6 biosynthetic process |
| positive regulation of neutrophil chemotaxis |
| positive regulation of granulocyte chemotaxis |
| positive regulation of neutrophil migration |
| regulation of neutrophil chemotaxis |
| MyD88-dependent toll-like receptor signaling pathway |
| positive regulation of interleukin-12 production |
| regulation of neutrophil migration |
| positive regulation of B cell proliferation |
| mRNA stabilization |
| regulation of granulocyte chemotaxis |
| regulation of interferon-beta production |
| RNA stabilization |
| positive regulation of interleukin-8 production |
| negative regulation of mRNA catabolic process |
| protein kinase C binding |
| regulation of interleukin-12 production |
| positive regulation of chemokine production |
| endocytic vesicle |
| negative regulation of RNA catabolic process |
| regulation of B cell proliferation |
| positive regulation of cytokine biosynthetic process |
| regulation of toll-like receptor signaling pathway |
| regulation of interleukin-8 production |
| phosphatidylinositol-4,5-bisphosphate binding |
| positive regulation of NIK/NF-kappaB signaling |
| regulation of chemokine production |
| negative regulation of mRNA metabolic process |
| protein binding, bridging |
| NIK/NF-kappaB signaling |
| positive regulation of tumor necrosis factor production |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| positive regulation of leukocyte chemotaxis |
| defense response to Gram-positive bacterium |
| positive regulation of protein binding |
| positive regulation of interleukin-6 production |
| ruffle membrane |
| toll-like receptor signaling pathway |
| regulation of cytokine biosynthetic process |
| regulation of NIK/NF-kappaB signaling |
| regulation of leukocyte chemotaxis |
| regulation of type I interferon production |
| pattern recognition receptor signaling pathway |
| positive regulation of leukocyte migration |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| positive regulation of chemotaxis |
| positive regulation of leukocyte proliferation |
| positive regulation of JNK cascade |
| regulation of interleukin-6 production |
| regulation of tumor necrosis factor production |
| regulation of tumor necrosis factor superfamily cytokine production |
| positive regulation of NF-kappaB transcription factor activity |
| positive regulation of B cell activation |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| positive regulation of binding |
| regulation of mRNA stability |
| regulation of RNA stability |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of JNK cascade |
| cellular response to molecule of bacterial origin |
| regulation of leukocyte migration |
| regulation of mRNA catabolic process |
| regulation of B cell activation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of chemotaxis |
| cellular response to biotic stimulus |
| regulation of protein binding |
| myeloid cell differentiation |
| regulation of leukocyte proliferation |
| regulation of stress-activated MAPK cascade |
| innate immune response-activating signal transduction |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of stress-activated protein kinase signaling cascade |
| negative regulation of cellular catabolic process |
| activation of innate immune response |
| positive regulation of DNA-binding transcription factor activity |
| regulation of ERK1 and ERK2 cascade |
| negative regulation of catabolic process |
| response to lipopolysaccharide |
| response to molecule of bacterial origin |
| activation of protein kinase activity |
| regulation of mRNA metabolic process |
| defense response to bacterium |
| positive regulation of innate immune response |
| positive regulation of lymphocyte activation |
| positive regulation of response to biotic stimulus |
| regulation of binding |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| regulation of DNA-binding transcription factor activity |
| positive regulation of cytokine production |
| regulation of innate immune response |
| positive regulation of defense response |
| protein heterodimerization activity |
| inflammatory response |
| positive regulation of cell migration |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| positive regulation of cell motility |
| regulation of response to biotic stimulus |
| posttranscriptional regulation of gene expression |
| positive regulation of protein kinase activity |
| positive regulation of cellular component movement |
| positive regulation of MAPK cascade |
| positive regulation of locomotion |
| hemopoiesis |
| immune response-activating signal transduction |
| positive regulation of kinase activity |
| immune response-regulating signaling pathway |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| hematopoietic or lymphoid organ development |
| activation of immune response |
| regulation of cell activation |
| immune system development |
| positive regulation of transferase activity |
| response to bacterium |
| regulation of cytokine production |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| regulation of defense response |
| innate immune response |
| regulation of multi-organism process |
| regulation of protein kinase activity |
| regulation of cellular catabolic process |
| regulation of cell migration |
| response to lipid |
| positive regulation of immune response |
| regulation of kinase activity |
| protein homodimerization activity |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| defense response to other organism |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of catabolic process |
| regulation of cellular component movement |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| identical protein binding |
| regulation of response to external stimulus |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| positive regulation of protein modification process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| defense response |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| regulation of response to stress |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| regulation of immune system process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| immune response |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| 2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311 | -1.72 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5912
- Expression level (log2 read counts): 2.0
Expression Distribution
TIRAP Expression in NALM6 Cells: 2.0
