TLL1
Gene Information
- Official Symbol: TLL1
- Official Name: tolloid like 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 7092
- UniProt: O43897
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes an astacin-like, zinc-dependent, metalloprotease that belongs to the peptidase M12A family. This protease processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Studies in mice suggest that this gene plays multiple roles in the development of mammalian heart, and is essential for the formation of the interventricular septum. Allelic variants of this gene are associated with atrial septal defect type 6. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011].
- UniProt Summary: Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13291
- Expression level (log2 read counts): -0.67
TLL1 Expression in NALM6 Cells: -0.67
