TMEM38A
Gene Information
- Official Symbol: TMEM38A
- Official Name: transmembrane protein 38A
- Aliases and Previous Symbols: N/A
- Entrez ID: 79041
- UniProt: Q9H6F2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. {ECO:0000250|UniProtKB:Q3TMP8}.
Pfam Domains GO Terms
Pfam Domains
| TRIC |
GO Terms
| release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| release of sequestered calcium ion into cytosol by endoplasmic reticulum |
| cellular response to caffeine |
| cellular response to purine-containing compound |
| sarcoplasmic reticulum calcium ion transport |
| response to diuretic |
| response to caffeine |
| regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| regulation of cardiac muscle contraction by calcium ion signaling |
| potassium channel activity |
| regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| sarcoplasmic reticulum membrane |
| protein homotrimerization |
| cellular response to alkaloid |
| protein trimerization |
| endoplasmic reticulum organization |
| release of sequestered calcium ion into cytosol |
| negative regulation of sequestering of calcium ion |
| calcium ion transmembrane import into cytosol |
| calcium ion transport into cytosol |
| regulation of cardiac muscle contraction |
| regulation of release of sequestered calcium ion into cytosol |
| cytosolic calcium ion transport |
| regulation of striated muscle contraction |
| regulation of calcium ion transport into cytosol |
| response to alkaloid |
| regulation of sequestering of calcium ion |
| calcium-mediated signaling |
| regulation of calcium ion transmembrane transport |
| response to purine-containing compound |
| potassium ion transmembrane transport |
| regulation of muscle contraction |
| potassium ion transport |
| cellular response to xenobiotic stimulus |
| calcium ion transmembrane transport |
| regulation of muscle system process |
| nuclear membrane |
| regulation of heart contraction |
| regulation of calcium ion transport |
| calcium ion transport |
| positive regulation of cytosolic calcium ion concentration |
| regulation of blood circulation |
| divalent metal ion transport |
| response to xenobiotic stimulus |
| divalent inorganic cation transport |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| second-messenger-mediated signaling |
| protein homooligomerization |
| regulation of metal ion transport |
| monovalent inorganic cation transport |
| cellular response to drug |
| endomembrane system organization |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| divalent inorganic cation homeostasis |
| protein complex oligomerization |
| cellular response to organic cyclic compound |
| cellular metal ion homeostasis |
| inorganic cation transmembrane transport |
| regulation of transmembrane transport |
| regulation of system process |
| cellular response to organonitrogen compound |
| cation transmembrane transport |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| cellular response to nitrogen compound |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| ion homeostasis |
| cation transport |
| cellular homeostasis |
| regulation of cellular localization |
| response to organic cyclic compound |
| ion transmembrane transport |
| response to organonitrogen compound |
| response to drug |
| response to nitrogen compound |
| chemical homeostasis |
| cellular response to endogenous stimulus |
| transmembrane transport |
| ion transport |
| response to endogenous stimulus |
| protein-containing complex assembly |
| homeostatic process |
| intracellular signal transduction |
| establishment of localization in cell |
| protein-containing complex subunit organization |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7263
- Expression level (log2 read counts): 2.49
Expression Distribution
TMEM38A Expression in NALM6 Cells: 2.49
