TMX3
Gene Information
- Official Symbol: TMX3
- Official Name: thioredoxin related transmembrane protein 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 54495
- UniProt: Q96JJ7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The canonical protein encoded by this gene has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This gene is expressed in many tissues but has its highest expression in heart and skeletal muscle. It is expressed in the retinal neuroepithelium and lens epithelium in the developing murine eye and haploinsufficiency of this gene in humans and zebrafish is associated with microphthalmia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017].
- UniProt Summary: Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. {ECO:0000269|PubMed:15623505}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17756
- Expression level (log2 read counts): 7.39
TMX3 Expression in NALM6 Cells: 7.39
