TRAK1
Gene Information
- Official Symbol: TRAK1
- Official Name: trafficking kinesin protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 22906
- UniProt: Q9UPV9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. {ECO:0000269|PubMed:18675823}.
Pfam Domains GO Terms
Pfam Domains
| Milton |
| HAP1 N |
GO Terms
| anterograde axonal transport of mitochondrion |
| TPR domain binding |
| axonal transport of mitochondrion |
| GABA receptor binding |
| mitochondrion distribution |
| mitochondrion transport along microtubule |
| establishment of mitochondrion localization, microtubule-mediated |
| myosin binding |
| establishment of mitochondrion localization |
| axonal growth cone |
| vesicle transport along microtubule |
| anterograde axonal transport |
| mitochondrion localization |
| vesicle cytoskeletal trafficking |
| endosome to lysosome transport |
| axonal transport |
| axon cytoplasm |
| dendrite morphogenesis |
| axo-dendritic transport |
| organelle transport along microtubule |
| positive regulation of axonogenesis |
| mitochondrial membrane |
| dendrite development |
| lysosomal transport |
| protein O-linked glycosylation |
| cell cortex |
| vacuolar transport |
| positive regulation of cell morphogenesis involved in differentiation |
| transport along microtubule |
| establishment of vesicle localization |
| cytoskeleton-dependent intracellular transport |
| microtubule-based transport |
| vesicle localization |
| regulation of axonogenesis |
| cytoplasmic vesicle |
| early endosome |
| protein glycosylation |
| macromolecule glycosylation |
| glycosylation |
| microtubule-based movement |
| positive regulation of neuron projection development |
| regulation of cell morphogenesis involved in differentiation |
| glycoprotein biosynthetic process |
| signaling receptor binding |
| protein targeting |
| establishment of organelle localization |
| positive regulation of neuron differentiation |
| positive regulation of cell projection organization |
| glycoprotein metabolic process |
| dendrite |
| cell morphogenesis involved in neuron differentiation |
| mitochondrion organization |
| positive regulation of neurogenesis |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| regulation of cell morphogenesis |
| cell projection morphogenesis |
| regulation of neuron projection development |
| cell part morphogenesis |
| positive regulation of nervous system development |
| positive regulation of cell development |
| cell morphogenesis involved in differentiation |
| organelle localization |
| carbohydrate derivative biosynthetic process |
| regulation of neuron differentiation |
| neuron projection development |
| microtubule-based process |
| regulation of plasma membrane bounded cell projection organization |
| perinuclear region of cytoplasm |
| regulation of cell projection organization |
| cell morphogenesis |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of nervous system development |
| regulation of cell development |
| positive regulation of cell differentiation |
| intracellular protein transport |
| neuron differentiation |
| carbohydrate derivative metabolic process |
| regulation of anatomical structure morphogenesis |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| positive regulation of cellular component organization |
| mitochondrion |
| positive regulation of developmental process |
| organonitrogen compound biosynthetic process |
| protein transport |
| intracellular transport |
| generation of neurons |
| peptide transport |
| movement of cell or subcellular component |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| neurogenesis |
| cell development |
| cellular macromolecule biosynthetic process |
| positive regulation of multicellular organismal process |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| establishment of localization in cell |
| nitrogen compound transport |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Centrinone 0.5μM R07 exp343 | 1.7 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11827
- Expression level (log2 read counts): 6.68
Expression Distribution
TRAK1 Expression in NALM6 Cells: 6.68
