TSC22D3
Gene Information
- Official Symbol: TSC22D3
- Official Name: TSC22 domain family member 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 1831
- UniProt: Q99576
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti- myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity). {ECO:0000250, ECO:0000269|PubMed:15031210}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 14852
- Expression level (log2 read counts): 0.93
TSC22D3 Expression in NALM6 Cells: 0.93
