TTC25

• Official Symbol: TTC25
• Official Name: tetratricopeptide repeat domain 25
• Aliases and Previous Symbols: N/A
• Entrez ID: 83538
• UniProt: Q96NG3
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: N/A

• Entrez Summary: This gene encodes a tetratricopeptide repeat domain-containing protein that localizes to ciliary axonmenes and plays a role in the docking of the outer dynein arm to cilia. Mutations in this gene cause severely reduced ciliary motility and the disorder CILD35 (ciliary dyskinesia,primary, 35). Primary ciliary dyskinesia is often associated with recurrent respiratory infections, immotile spermatozoa, and situs inversus; an inversion in left-right body symmetry. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017].
• UniProt Summary: Required for the docking of the outer dynein arm to cilia, hence plays an essential role in cilia motility. {ECO:0000269|PubMed:27486780}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 12041
• Expression level (log2 read counts): -3.42

Expression Distribution

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TTC25 Expression in NALM6 Cells: -3.42