TUBB8
Gene Information
- Official Symbol: TUBB8
- Official Name: tubulin beta 8 class VIII
- Aliases and Previous Symbols: N/A
- Entrez ID: 347688
- UniProt: Q3ZCM7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene represents the primary beta-tubulin subunit of oocytes and the early embryo. Defects in this gene, which is primate-specific, are a cause of oocyte maturation defect 2 and infertility. [provided by RefSeq, Mar 2016].
- UniProt Summary: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871). {ECO:0000250, ECO:0000269|PubMed:26789871}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 1889
- Expression level (log2 read counts): 0.12
TUBB8 Expression in NALM6 Cells: 0.12
