UniProt Summary: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity). {ECO:0000250}.
Pfam DomainsGO Terms
Pfam Domains
Tubulin C
Misat Myo SegII
Tubulin
GO Terms
meiotic spindle organization
gamma-tubulin complex
microtubule nucleation
pericentriolar material
microtubule polymerization
spindle microtubule
microtubule polymerization or depolymerization
cytoplasmic microtubule
cytoplasmic microtubule organization
mitotic spindle organization
protein polymerization
structural constituent of cytoskeleton
microtubule cytoskeleton organization involved in mitosis
mitotic sister chromatid segregation
spindle
sister chromatid segregation
mitotic nuclear division
microtubule cytoskeleton
spindle organization
meiotic cell cycle process
structural molecule activity
nuclear chromosome segregation
meiotic cell cycle
chromosome segregation
nuclear division
organelle fission
microtubule
GTPase activity
GTP binding
supramolecular fiber organization
microtubule cytoskeleton organization
centrosome
mitotic cell cycle process
microtubule-based process
mitotic cell cycle
cellular protein-containing complex assembly
cell cycle process
chromosome organization
cytoskeleton organization
cell cycle
reproductive process
reproduction
protein-containing complex assembly
protein-containing complex subunit organization
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739