UniProt Summary: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. {ECO:0000269|PubMed:20061386}.
Pfam DomainsGO Terms
Pfam Domains
UQ con
GO Terms
ubiquitin conjugating enzyme activity
protein K48-linked ubiquitination
ubiquitin-protein transferase activity
protein polyubiquitination
protein ubiquitination
protein modification by small protein conjugation
protein modification by small protein conjugation or removal
ATP binding
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739