UGT2B28
Gene Information
- Official Symbol: UGT2B28
- Official Name: UDP glucuronosyltransferase family 2 member B28
- Aliases and Previous Symbols: N/A
- Entrez ID: 54490
- UniProt: Q9BY64
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Two transcript variants encoding different isoforms have been found for this gene. While both isoforms are targeted to the endoplasmic reticulum, only the longer isoform appears to be active. [provided by RefSeq, May 2011].
- UniProt Summary: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta- diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active. {ECO:0000269|PubMed:11300766}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17147
- Expression level (log2 read counts): -7.68
UGT2B28 Expression in NALM6 Cells: -7.68
