Entrez Summary: This gene encodes a member of the junctional adhesion molecule (JAM) family. The encoded protein contains multiple glycosylation sites at the N-terminal region, and multiple phosphorylation sites and glutamic acid/proline (EP) repeats at the C-terminal region. The gene is expressed in normal stomach and testis, as well as in gastric, esophageal and ovarian cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
V-set
I-set
GO Terms
maintenance of gastrointestinal epithelium
epithelial structure maintenance
epithelial cell morphogenesis
digestive system process
digestion
tissue homeostasis
epithelial cell development
basolateral plasma membrane
multicellular organismal homeostasis
anatomical structure homeostasis
cell morphogenesis involved in differentiation
epithelial cell differentiation
cell morphogenesis
cellular component morphogenesis
epithelium development
homeostatic process
cell development
tissue development
system process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)