UniProt Summary: Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. {ECO:0000269|PubMed:9536085}.
Pfam DomainsGO Terms
Pfam Domains
wnt
GO Terms
determination of dorsal identity
determination of dorsal/ventral asymmetry
beta-catenin destruction complex disassembly
receptor ligand activity
frizzled binding
cellular response to retinoic acid
dorsal/ventral pattern formation
canonical Wnt signaling pathway
response to retinoic acid
determination of bilateral symmetry
specification of symmetry
response to estradiol
gastrulation
cellular response to acid chemical
protein-containing complex disassembly
cell fate commitment
regionalization
response to acid chemical
Wnt signaling pathway
cell-cell signaling by wnt
cellular component disassembly
cell surface receptor signaling pathway involved in cell-cell signaling
pattern specification process
cellular response to lipid
embryonic morphogenesis
response to lipid
response to hormone
response to organic cyclic compound
embryo development
neuron differentiation
cellular response to oxygen-containing compound
cell-cell signaling
response to endogenous stimulus
generation of neurons
response to oxygen-containing compound
extracellular space
neurogenesis
protein-containing complex subunit organization
extracellular region
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739