YWHAZ
Gene Information
- Official Symbol: YWHAZ
- Official Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
- Aliases and Previous Symbols: N/A
- Entrez ID: 7534
- UniProt: P63104
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| 14-3-3 |
GO Terms
| synaptic target recognition |
| Golgi reassembly |
| establishment of Golgi localization |
| organelle inheritance |
| Golgi inheritance |
| regulation of synapse maturation |
| Golgi localization |
| positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| hippocampal mossy fiber to CA3 synapse |
| positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| neuron recognition |
| positive regulation of establishment of protein localization to mitochondrion |
| regulation of mitochondrial membrane permeability |
| regulation of establishment of protein localization to mitochondrion |
| regulation of membrane permeability |
| melanosome |
| positive regulation of mitochondrion organization |
| positive regulation of protein localization to membrane |
| ion channel binding |
| mitochondrial membrane organization |
| Golgi organization |
| platelet activation |
| vesicle |
| blood microparticle |
| positive regulation of apoptotic signaling pathway |
| regulation of mRNA stability |
| regulation of mitochondrion organization |
| regulation of RNA stability |
| regulation of protein localization to membrane |
| regulation of mRNA catabolic process |
| mitochondrial transport |
| regulation of synapse organization |
| regulation of synapse structure or activity |
| cell recognition |
| protein domain specific binding |
| ubiquitin protein ligase binding |
| blood coagulation |
| coagulation |
| hemostasis |
| cadherin binding |
| positive regulation of cellular protein localization |
| regulation of mRNA metabolic process |
| transcription factor binding |
| glutamatergic synapse |
| protein targeting |
| establishment of organelle localization |
| regulation of apoptotic signaling pathway |
| focal adhesion |
| endomembrane system organization |
| mitochondrion organization |
| positive regulation of establishment of protein localization |
| protein kinase binding |
| wound healing |
| regulation of body fluid levels |
| posttranscriptional regulation of gene expression |
| regulation of cellular protein localization |
| response to wounding |
| organelle localization |
| positive regulation of organelle organization |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| cytokine-mediated signaling pathway |
| positive regulation of cell death |
| regulation of establishment of protein localization |
| neuron development |
| regulation of cellular catabolic process |
| membrane organization |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| regulation of cellular localization |
| regulation of nervous system development |
| positive regulation of transport |
| regulation of catabolic process |
| negative regulation of cell death |
| intracellular protein transport |
| cellular response to cytokine stimulus |
| neuron differentiation |
| regulation of protein localization |
| identical protein binding |
| cell activation |
| response to cytokine |
| positive regulation of cellular component organization |
| mitochondrion |
| regulation of organelle organization |
| RNA binding |
| protein transport |
| intracellular transport |
| generation of neurons |
| peptide transport |
| regulation of apoptotic process |
| regulation of programmed cell death |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| extracellular space |
| establishment of protein localization |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| MS023 7μM R03 exp135 | 2.24 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5375
- Expression level (log2 read counts): 8.73
Expression Distribution
YWHAZ Expression in NALM6 Cells: 8.73
