ZBTB42
Gene Information
- Official Symbol: ZBTB42
- Official Name: zinc finger and BTB domain containing 42
- Aliases and Previous Symbols: N/A
- Entrez ID: 100128927
- UniProt: B2RXF5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the C2H2 zinc finger protein family. This protein is predicted to have a pox virus and zinc finger (POZ) domain at the N-terminus and four zinc finger domains at the C-terminus. In human and mouse, the protein localizes to the nuclei of skeletal muscle cells. Knockdown of this gene in zebrafish results in abnormal skeletal muscle development and myofibrillar disorganization. A novel homozygous variant of the human gene has been associated with lethal congenital contracture syndrome, an autosomal recessive disorder that results in muscle wasting. [provided by RefSeq, Mar 2015].
- UniProt Summary: Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. {ECO:0000250|UniProtKB:Q811H0}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 9277
- Expression level (log2 read counts): 2.17
ZBTB42 Expression in NALM6 Cells: 2.17
