Entrez Summary: This gene encodes a member of the zinc finger domain-containing protein family. This family member has a C-terminal zinc finger domain that is characterized by four cysteine residues and two histidine residues, and it also includes a coiled-coil region. This protein has been detected as an autoantigen in hepatocellular carcinoma patients. This gene has been identified as a potential candidate for X-linked cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
zf-C4H2
GO Terms
spinal cord motor neuron differentiation
neuromuscular junction development
ventral spinal cord development
cell differentiation in spinal cord
spinal cord development
central nervous system neuron differentiation
postsynaptic membrane
synapse organization
positive regulation of neuron differentiation
positive regulation of neurogenesis
positive regulation of nervous system development
positive regulation of cell development
cell junction
regulation of neuron differentiation
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
central nervous system development
neuron differentiation
positive regulation of developmental process
generation of neurons
neurogenesis
positive regulation of multicellular organismal process
regulation of cell differentiation
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/694