ZFAND2B
Gene Information
- Official Symbol: ZFAND2B
- Official Name: zinc finger AN1-type containing 2B
- Aliases and Previous Symbols: N/A
- Entrez ID: 130617
- UniProt: Q8WV99
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| zf-AN1 |
GO Terms
| K48-linked polyubiquitin modification-dependent protein binding |
| SRP-dependent cotranslational protein targeting to membrane, translocation |
| regulation of insulin-like growth factor receptor signaling pathway |
| intracellular protein transmembrane transport |
| proteasome complex |
| protein transmembrane transport |
| ubiquitin binding |
| SRP-dependent cotranslational protein targeting to membrane |
| cotranslational protein targeting to membrane |
| anchored component of membrane |
| protein targeting to ER |
| establishment of protein localization to endoplasmic reticulum |
| protein localization to endoplasmic reticulum |
| protein targeting to membrane |
| establishment of protein localization to membrane |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| proteasomal protein catabolic process |
| protein targeting |
| establishment of protein localization to organelle |
| protein localization to membrane |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| protein catabolic process |
| protein localization to organelle |
| zinc ion binding |
| cellular macromolecule catabolic process |
| endoplasmic reticulum membrane |
| intracellular protein transport |
| endoplasmic reticulum |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| proteolysis |
| transmembrane transport |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| organic substance catabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| iCRT14 30μM R08 exp492 | -2.32 |
| 6-Thio-2-deoxyguanosine 2μM R06 exp259 | -2.21 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12929
- Expression level (log2 read counts): 4.31
Expression Distribution
ZFAND2B Expression in NALM6 Cells: 4.31
