Pfam Domains GO Terms
| FYVE |
| negative regulation of epidermal growth factor-activated receptor activity |
| regulation of epidermal growth factor-activated receptor activity |
| negative regulation of protein tyrosine kinase activity |
| phosphatidylinositol-3-phosphate binding |
| negative regulation of epidermal growth factor receptor signaling pathway |
| negative regulation of peptidyl-tyrosine phosphorylation |
| negative regulation of ERBB signaling pathway |
| negative regulation of signaling receptor activity |
| regulation of epidermal growth factor receptor signaling pathway |
| regulation of protein tyrosine kinase activity |
| regulation of ERBB signaling pathway |
| early endosome membrane |
| regulation of signaling receptor activity |
| negative regulation of protein kinase activity |
| negative regulation of kinase activity |
| regulation of peptidyl-tyrosine phosphorylation |
| negative regulation of transferase activity |
| negative regulation of protein phosphorylation |
| negative regulation of phosphorylation |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of kinase activity |
| regulation of transferase activity |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of protein phosphorylation |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution