ZMAT3
Gene Information
- Official Symbol: ZMAT3
- Official Name: zinc finger matrin-type 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 64393
- UniProt: Q9HA38
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008].
- UniProt Summary: Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus. {ECO:0000269|PubMed:11571644}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 18392
- Expression level (log2 read counts): 5.62
ZMAT3 Expression in NALM6 Cells: 5.62
