ZMPSTE24
Gene Information
- Official Symbol: ZMPSTE24
- Official Name: zinc metallopeptidase STE24
- Aliases and Previous Symbols: N/A
- Entrez ID: 10269
- UniProt: O75844
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq, Jul 2008].
- UniProt Summary: Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C.
Pfam Domains GO Terms
Pfam Domains
| Peptidase M48 |
GO Terms
| histone H2B-K5 acetylation |
| regulation of termination of RNA polymerase I transcription |
| maintenance of rDNA |
| prenylated protein catabolic process |
| CAAX-box protein processing |
| calcium ion import into sarcoplasmic reticulum |
| DNA hypomethylation |
| hypomethylation of CpG island |
| histone H2B acetylation |
| CAAX-box protein maturation |
| histone H2A phosphorylation |
| regulation of mitotic cell cycle DNA replication |
| regulation of DNA-templated transcription, termination |
| CAMKK-AMPK signaling cascade |
| calmodulin dependent kinase signaling pathway |
| inflammatory cell apoptotic process |
| maintenance of DNA repeat elements |
| response to DNA damage checkpoint signaling |
| response to DNA integrity checkpoint signaling |
| response to cell cycle checkpoint signaling |
| regulation of histone H4-K16 acetylation |
| negative regulation of production of miRNAs involved in gene silencing by miRNA |
| metalloexopeptidase activity |
| regulation of histone H4 acetylation |
| regulation of RNA polymerase II regulatory region sequence-specific DNA binding |
| negative regulation of gene silencing by miRNA |
| sarcoplasmic reticulum calcium ion transport |
| negative regulation of posttranscriptional gene silencing |
| negative regulation of gene silencing by RNA |
| regulation of nuclear cell cycle DNA replication |
| determination of adult lifespan |
| cardiac muscle fiber development |
| regulation of production of miRNAs involved in gene silencing by miRNA |
| regulation of production of small RNA involved in gene silencing by RNA |
| regulation of ventricular cardiac muscle cell membrane repolarization |
| regulation of DNA methylation |
| regulation of cardiac muscle cell membrane repolarization |
| adult walking behavior |
| histone phosphorylation |
| cellular response to gamma radiation |
| walking behavior |
| regulation of transcription by RNA polymerase I |
| growth plate cartilage development |
| regulation of DNA damage response, signal transduction by p53 class mediator |
| regulation of membrane repolarization |
| multicellular organism aging |
| negative regulation of gene silencing |
| regulation of hormone metabolic process |
| regulation of cellular senescence |
| endochondral bone growth |
| calcium ion import |
| cartilage development involved in endochondral bone morphogenesis |
| thymus development |
| bone growth |
| nuclear inner membrane |
| bone mineralization |
| regulation of cell aging |
| regulation of transcription regulatory region DNA binding |
| nuclear envelope organization |
| regulation of DNA-dependent DNA replication |
| ventricular cardiac muscle tissue development |
| response to gamma radiation |
| regulation of histone acetylation |
| muscle fiber development |
| cardiac muscle cell development |
| regulation of peptidyl-lysine acetylation |
| cardiac cell development |
| regulation of multicellular organism growth |
| cellular response to ionizing radiation |
| regulation of protein acetylation |
| hair follicle development |
| endochondral bone morphogenesis |
| skin epidermis development |
| regulation of defense response to virus |
| regulation of bone mineralization |
| hair cycle process |
| molting cycle process |
| adult locomotory behavior |
| regulation of fibroblast proliferation |
| multicellular organism growth |
| kidney morphogenesis |
| regulation of gene silencing by miRNA |
| cardiac muscle cell differentiation |
| regulation of gene silencing by RNA |
| regulation of posttranscriptional gene silencing |
| hair cycle |
| molting cycle |
| biomineral tissue development |
| regulation of biomineral tissue development |
| regulation of biomineralization |
| cardiac conduction |
| biomineralization |
| organ growth |
| regulation of TOR signaling |
| double-stranded DNA binding |
| metalloendopeptidase activity |
| integral component of endoplasmic reticulum membrane |
| neuromuscular process |
| regulation of DNA replication |
| bone morphogenesis |
| histone acetylation |
| regulation of glucose metabolic process |
| regulation of protein complex disassembly |
| cardiocyte differentiation |
| internal peptidyl-lysine acetylation |
| peptidyl-lysine acetylation |
| internal protein amino acid acetylation |
| regulation of DNA binding |
| liver development |
| cardiac ventricle development |
| hepaticobiliary system development |
| regulation of gene silencing |
| nucleus organization |
| multicellular organismal signaling |
| striated muscle cell development |
| regulation of cellular carbohydrate metabolic process |
| protein acetylation |
| adult behavior |
| regulation of histone modification |
| calcium-mediated signaling |
| muscle cell development |
| response to ionizing radiation |
| regulation of cell shape |
| protein processing |
| cardiac muscle tissue development |
| cardiac chamber development |
| cartilage development |
| cellular response to radiation |
| regulation of signal transduction by p53 class mediator |
| protein acylation |
| regulation of chromatin organization |
| regulation of ossification |
| locomotory behavior |
| bone development |
| striated muscle cell differentiation |
| regulation of carbohydrate metabolic process |
| cellular response to biotic stimulus |
| regulation of response to DNA damage stimulus |
| connective tissue development |
| protein maturation |
| regulation of stress-activated protein kinase signaling cascade |
| skeletal system morphogenesis |
| regulation of heart contraction |
| muscle cell differentiation |
| calcium ion transport |
| heart morphogenesis |
| ossification |
| kidney development |
| aging |
| striated muscle tissue development |
| renal system development |
| regulation of blood circulation |
| divalent metal ion transport |
| muscle tissue development |
| divalent inorganic cation transport |
| peptidyl-lysine modification |
| cellular response to environmental stimulus |
| cellular response to abiotic stimulus |
| urogenital system development |
| regulation of developmental growth |
| regulation of autophagy |
| second-messenger-mediated signaling |
| regulation of chromosome organization |
| regulation of DNA metabolic process |
| histone modification |
| covalent chromatin modification |
| regulation of binding |
| skin development |
| developmental growth |
| growth |
| regulation of lipid metabolic process |
| gland development |
| epidermis development |
| endomembrane system organization |
| regulation of small molecule metabolic process |
| regulation of membrane potential |
| response to radiation |
| regulation of immune effector process |
| muscle structure development |
| regulation of ion transmembrane transport |
| regulation of cell morphogenesis |
| skeletal system development |
| DNA repair |
| regulation of response to biotic stimulus |
| heart development |
| modification-dependent protein catabolic process |
| regulation of hormone levels |
| modification-dependent macromolecule catabolic process |
| regulation of transmembrane transport |
| behavior |
| regulation of system process |
| proteolysis involved in cellular protein catabolic process |
| protein-containing complex |
| hematopoietic or lymphoid organ development |
| cellular protein catabolic process |
| regulation of mitotic cell cycle |
| metal ion transport |
| immune system development |
| regulation of growth |
| protein catabolic process |
| regulation of ion transport |
| chromatin organization |
| regulation of cellular response to stress |
| DNA metabolic process |
| regulation of cell cycle process |
| regulation of defense response |
| cellular response to DNA damage stimulus |
| regulation of multi-organism process |
| cation transport |
| regulation of cellular catabolic process |
| membrane organization |
| circulatory system development |
| peptidyl-amino acid modification |
| cellular macromolecule catabolic process |
| apoptotic process |
| animal organ morphogenesis |
| cellular lipid metabolic process |
| protein phosphorylation |
| regulation of catabolic process |
| macromolecule catabolic process |
| programmed cell death |
| organonitrogen compound catabolic process |
| regulation of anatomical structure morphogenesis |
| chromosome organization |
| cell death |
| regulation of response to external stimulus |
| epithelium development |
| response to abiotic stimulus |
| regulation of cell cycle |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| proteolysis |
| phosphorylation |
| regulation of organelle organization |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| ion transport |
| nervous system process |
| negative regulation of nucleobase-containing compound metabolic process |
| response to endogenous stimulus |
| regulation of response to stress |
| intracellular transport |
| regulation of cell population proliferation |
| cell development |
| regulation of immune system process |
| intracellular signal transduction |
| cellular response to stress |
| negative regulation of gene expression |
| tissue development |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| regulation of transport |
| system process |
| positive regulation of gene expression |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16556
- Expression level (log2 read counts): 6.58
Expression Distribution
ZMPSTE24 Expression in NALM6 Cells: 6.58
