UniProt Summary: Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins. {ECO:0000250|UniProtKB:Q8BGV5}.
Pfam DomainsGO Terms
Pfam Domains
KRAB
zf-C2H2
GO Terms
BMP signaling pathway
response to BMP
cellular response to BMP stimulus
transmembrane receptor protein serine/threonine kinase signaling pathway
cellular response to growth factor stimulus
response to growth factor
enzyme linked receptor protein signaling pathway
zinc ion binding
negative regulation of transcription by RNA polymerase II
negative regulation of transcription, DNA-templated
cellular response to endogenous stimulus
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
response to endogenous stimulus
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
negative regulation of gene expression
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)