UniProt Summary: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.
Pfam DomainsGO Terms
Pfam Domains
TFIIS C
GO Terms
RNA polymerase I activity
RNA polymerase I complex
mRNA cleavage
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
DNA-directed 5-3 RNA polymerase activity
transcription initiation from RNA polymerase I promoter
transcription by RNA polymerase I
positive regulation of gene expression, epigenetic
DNA-templated transcription, termination
DNA-templated transcription, elongation
RNA phosphodiester bond hydrolysis
nucleic acid binding
DNA-templated transcription, initiation
regulation of gene expression, epigenetic
nucleic acid phosphodiester bond hydrolysis
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
mRNA metabolic process
zinc ion binding
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
positive regulation of gene expression
gene expression
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 351/726