AATK
Gene Information
- Official Symbol: AATK
- Official Name: apoptosis associated tyrosine kinase
- Aliases and Previous Symbols: N/A
- Entrez ID: 9625
- UniProt: Q6ZMQ8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011].
- UniProt Summary: May be involved in neuronal differentiation. {ECO:0000269|PubMed:10837911}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3336
- Expression level (log2 read counts): -5.28
AATK Expression in NALM6 Cells: -5.28
