ABCC6
Gene Information
- Official Symbol: ABCC6
- Official Name: ATP binding cassette subfamily C member 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 368
- UniProt: O95255
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008].
- UniProt Summary: Isoform 1: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS). {ECO:0000269|PubMed:11880368}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 2912
- Expression level (log2 read counts): 2.75
ABCC6 Expression in NALM6 Cells: 2.75
