ACADS
Gene Information
- Official Symbol: ACADS
- Official Name: acyl-CoA dehydrogenase short chain
- Aliases and Previous Symbols: N/A
- Entrez ID: 35
- UniProt: P16219
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with short-chain acyl-CoA dehydrogenase (SCAD) deficiency. Alternative splicing results in two variants which encode different isoforms. [provided by RefSeq, Oct 2014].
- UniProt Summary: Introduces a double bond at position 2 in saturated acyl-CoA's of short chain length, i.e. less than 6 carbon atoms. {ECO:0000250|UniProtKB:P15651}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13086
- Expression level (log2 read counts): 3.9
ACADS Expression in NALM6 Cells: 3.9
