ACPL2
Gene Information
- Official Symbol: PXYLP1
- Official Name: 2-phosphoxylose phosphatase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 92370
- UniProt: Q8TE99
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1- 4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains. {ECO:0000269|PubMed:24425863}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 9382
- Expression level (log2 read counts): 3.62
ACPL2 Expression in NALM6 Cells: 3.62
