ACTL6A

Gene Information

Official Symbol: ACTL6A
Official Name: actin like 6A
Aliases and Previous Symbols: N/A
Entrez ID: 86
UniProt: O96019
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000250|UniProtKB:Q9Z2N8, ECO:0000269|PubMed:14966270, ECO:0000303|PubMed:15196461, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-2.24
Q15 1 to 2μM on day4 R04 exp164	-2.13
Torin1 0.08μM R02 exp82	-2.01
Celastrol 0.12μM R05 exp225	-1.91
Radicicol 0.16μM R05 exp242	-1.82
A-366 10μM R03 exp115	-1.76
CoCl2 18μM R07 exp346	-1.73
NMS-873 0.07μM R07 exp380	-1.7
SNS-032 25μM R07 exp401	1.81
Fluvastatin 2.2μM R06 exp282	1.9
Ibrutinib 10μM R08 exp442	1.94

Global Fraction of Cell Lines Where Essential: 708/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	25/25
breast	32/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	11/13
fibroblast	1/1
gastric	15/15
kidney	20/21
liver	20/20
lung	69/75
lymphocyte	14/14
ovary	26/26
pancreas	23/24
peripheral nervous system	11/16
plasma cell	14/15
prostate	1/1
skin	24/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 593
Expression level (log2 read counts): 6.52

Expression Distribution