ADAMTS3
Gene Information
- Official Symbol: ADAMTS3
- Official Name: ADAM metallopeptidase with thrombospondin type 1 motif 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 9508
- UniProt: O15072
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016].
- UniProt Summary: Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 18286
- Expression level (log2 read counts): 3.43
ADAMTS3 Expression in NALM6 Cells: 3.43
