ADAP2
Gene Information
- Official Symbol: ADAP2
- Official Name: ArfGAP with dual PH domains 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 55803
- UniProt: Q9NPF8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene binds beta-tubulin and increases the stability of microtubules. The encoded protein can also translocate to the cell membrane and bind phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). In addition, this protein is a GTPase-activating protein for ADP ribosylation factor 6 and may be able to block the entry of some RNA viruses. [provided by RefSeq, Oct 2016].
- UniProt Summary: GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. {ECO:0000269|PubMed:14690521, ECO:0000305}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 11567
- Expression level (log2 read counts): 0.65
ADAP2 Expression in NALM6 Cells: 0.65
