UniProt Summary: Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA.
Pfam DomainsGO Terms
Pfam Domains
A deamin
dsrm
GO Terms
adenosine deaminase activity
double-stranded RNA adenosine deaminase activity
tRNA-specific adenosine deaminase activity
adenosine to inosine editing
base conversion or substitution editing
single-stranded RNA binding
double-stranded RNA binding
RNA modification
mRNA processing
mRNA metabolic process
nucleolus
RNA processing
RNA binding
RNA metabolic process
gene expression
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739