ADRA1A
Gene Information
- Official Symbol: ADRA1A
- Official Name: adrenoceptor alpha 1A
- Aliases and Previous Symbols: N/A
- Entrez ID: 148
- UniProt: P35348
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| 7tm 1 |
| 7TM GPCR Srsx |
GO Terms
| negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure |
| regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback |
| baroreceptor response to increased systemic arterial blood pressure |
| positive regulation of the force of heart contraction by epinephrine-norepinephrine |
| alpha1-adrenergic receptor activity |
| norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure |
| positive regulation of the force of heart contraction by chemical signal |
| regulation of systemic arterial blood pressure by baroreceptor feedback |
| pilomotor reflex |
| positive regulation of heart rate by epinephrine-norepinephrine |
| neuron-glial cell signaling |
| positive regulation of blood pressure by epinephrine-norepinephrine |
| regulation of the force of heart contraction by chemical signal |
| positive regulation of non-membrane spanning protein tyrosine kinase activity |
| micturition |
| regulation of non-membrane spanning protein tyrosine kinase activity |
| regulation of systemic arterial blood pressure by norepinephrine-epinephrine |
| cell growth involved in cardiac muscle cell development |
| physiological cardiac muscle hypertrophy |
| physiological muscle hypertrophy |
| positive regulation of action potential |
| positive regulation of protein kinase C signaling |
| negative regulation of heart rate |
| nervous system process involved in regulation of systemic arterial blood pressure |
| positive regulation of cardiac muscle contraction |
| positive regulation of synaptic transmission, GABAergic |
| dopaminergic synapse |
| positive regulation of systemic arterial blood pressure |
| positive regulation of striated muscle contraction |
| adult heart development |
| regulation of protein kinase C signaling |
| adrenergic receptor activity |
| negative regulation of systemic arterial blood pressure |
| reflex |
| negative regulation of Rho protein signal transduction |
| adenylate cyclase-activating adrenergic receptor signaling pathway |
| adrenergic receptor signaling pathway |
| negative regulation of heart contraction |
| positive regulation of heart rate |
| cardiac muscle tissue growth |
| regulation of the force of heart contraction |
| heart growth |
| cardiac muscle hypertrophy |
| striated muscle hypertrophy |
| positive regulation of cardiac muscle hypertrophy |
| vasoconstriction |
| positive regulation of vasoconstriction |
| positive regulation of smooth muscle contraction |
| positive regulation of muscle hypertrophy |
| activation of phospholipase C activity |
| regulation of synaptic transmission, GABAergic |
| muscle hypertrophy |
| negative regulation of blood circulation |
| positive regulation of blood pressure |
| positive regulation of heart contraction |
| negative regulation of blood vessel diameter |
| excretion |
| positive regulation of phospholipase C activity |
| T-tubule |
| negative regulation of blood pressure |
| integral component of postsynaptic membrane |
| positive regulation of muscle contraction |
| regulation of systemic arterial blood pressure mediated by a chemical signal |
| regulation of phospholipase C activity |
| regulation of action potential |
| smooth muscle contraction |
| negative regulation of Ras protein signal transduction |
| positive regulation of protein tyrosine kinase activity |
| regulation of cardiac muscle hypertrophy |
| regulation of vasoconstriction |
| integral component of presynaptic membrane |
| negative regulation of small GTPase mediated signal transduction |
| positive regulation of phospholipase activity |
| regulation of muscle hypertrophy |
| regulation of smooth muscle contraction |
| cardiac muscle cell development |
| cardiac cell development |
| GABA-ergic synapse |
| positive regulation of blood circulation |
| positive regulation of lipase activity |
| regulation of phospholipase activity |
| calcium ion transport into cytosol |
| caveola |
| regulation of cardiac muscle contraction |
| regulation of synaptic vesicle exocytosis |
| negative regulation of autophagy |
| regulation of muscle adaptation |
| developmental cell growth |
| cardiac muscle cell differentiation |
| cytosolic calcium ion transport |
| regulation of protein tyrosine kinase activity |
| cell growth |
| regulation of striated muscle contraction |
| regulation of systemic arterial blood pressure |
| phospholipase C-activating G protein-coupled receptor signaling pathway |
| organ growth |
| regulation of heart rate |
| regulation of lipase activity |
| regulation of neurotransmitter secretion |
| renal system process |
| regulation of synaptic vesicle cycle |
| cardiocyte differentiation |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| Z disc |
| striated muscle cell development |
| regulation of blood vessel diameter |
| regulation of tube diameter |
| regulation of tube size |
| regulation of neurotransmitter transport |
| regulation of Rho protein signal transduction |
| cAMP-mediated signaling |
| muscle cell development |
| positive regulation of synaptic transmission |
| regulation of muscle contraction |
| cardiac muscle tissue development |
| regulation of regulated secretory pathway |
| vascular process in circulatory system |
| cyclic-nucleotide-mediated signaling |
| regulation of blood pressure |
| positive regulation of peptidyl-tyrosine phosphorylation |
| striated muscle cell differentiation |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of exocytosis |
| regulation of muscle system process |
| nuclear membrane |
| regulation of heart contraction |
| regulation of Ras protein signal transduction |
| muscle cell differentiation |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| calcium ion transport |
| muscle contraction |
| negative regulation of cellular catabolic process |
| regulation of peptidyl-tyrosine phosphorylation |
| aging |
| positive regulation of cytosolic calcium ion concentration |
| striated muscle tissue development |
| regulation of blood circulation |
| regulation of ERK1 and ERK2 cascade |
| divalent metal ion transport |
| muscle tissue development |
| muscle system process |
| divalent inorganic cation transport |
| negative regulation of catabolic process |
| regulation of cytosolic calcium ion concentration |
| regulation of autophagy |
| second-messenger-mediated signaling |
| regulation of small GTPase mediated signal transduction |
| glutamatergic synapse |
| regulation of neurotransmitter levels |
| developmental growth |
| blood circulation |
| growth |
| circulatory system process |
| regulation of membrane potential |
| cellular calcium ion homeostasis |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| muscle structure development |
| protein heterodimerization activity |
| divalent inorganic cation homeostasis |
| negative regulation of intracellular signal transduction |
| regulation of anatomical structure size |
| heart development |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| regulation of vesicle-mediated transport |
| cellular metal ion homeostasis |
| positive regulation of kinase activity |
| regulation of system process |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| positive regulation of transferase activity |
| negative regulation of cell population proliferation |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| positive regulation of hydrolase activity |
| ion homeostasis |
| regulation of protein kinase activity |
| regulation of secretion |
| cation transport |
| regulation of cellular catabolic process |
| circulatory system development |
| regulation of kinase activity |
| cellular homeostasis |
| response to hormone |
| regulation of cellular localization |
| apoptotic process |
| regulation of transferase activity |
| regulation of catabolic process |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| response to drug |
| programmed cell death |
| positive regulation of phosphorylation |
| cell death |
| chemical homeostasis |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| G protein-coupled receptor signaling pathway |
| negative regulation of cell communication |
| negative regulation of signaling |
| ion transport |
| nervous system process |
| integral component of plasma membrane |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| homeostatic process |
| cell development |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| regulation of transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5000
- Expression level (log2 read counts): 2.11
Expression Distribution
ADRA1A Expression in NALM6 Cells: 2.11
