Entrez Summary: This gene encodes a metallocarboxypeptidase involved in protein deglutamylation and a member of the peptidase M14 family of proteins. The encoded protein has been described as a 'dual-functional' deglutamylase that can remove glutamate residues from both carboxyl termini and side chains of protein substrates. This deglutamylase activity may be important in antiviral immunity. Mutations in this gene are associated with retinitis pigmentosa. [provided by RefSeq, Jul 2016].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
Peptidase M14
GO Terms
protein branching point deglutamylation
protein deglutamylation
peptidyl-glutamic acid modification
metallocarboxypeptidase activity
tubulin binding
intercellular bridge
mitotic spindle
microtubule cytoskeleton
midbody
defense response to virus
response to virus
zinc ion binding
peptidyl-amino acid modification
defense response to other organism
immune effector process
proteolysis
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)