AKIP1
Gene Information
- Official Symbol: AKIP1
- Official Name: A-kinase interacting protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 56672
- UniProt: Q9NQ31
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011].
- UniProt Summary: Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. {ECO:0000269|PubMed:18178962, ECO:0000269|PubMed:20562110}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4523
- Expression level (log2 read counts): 4.03
AKIP1 Expression in NALM6 Cells: 4.03
