AMHR2
Gene Information
- Official Symbol: AMHR2
- Official Name: anti-Mullerian hormone receptor type 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 269
- UniProt: Q16671
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009].
- UniProt Summary: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3393
- Expression level (log2 read counts): -6.6
AMHR2 Expression in NALM6 Cells: -6.6
