APCS

Gene Information

Official Symbol: APCS
Official Name: amyloid P component, serum
Aliases and Previous Symbols: N/A
Entrez ID: 325
UniProt: P02743
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.

Pfam Domains GO Terms

Pfam Domains

Pentaxin

GO Terms

modulation by host of viral catalytic activity

negative regulation by host of symbiont catalytic activity

modulation by host of viral exo-alpha-sialidase activity

negative regulation by host of viral glycoprotein metabolic process

negative regulation of exo-alpha-sialidase activity

negative regulation by host of viral exo-alpha-sialidase activity

modulation by host of viral glycoprotein metabolic process

modulation by host of viral molecular function

modulation by host of symbiont catalytic activity

regulation of exo-alpha-sialidase activity

negative regulation of catalytic activity in other organism involved in symbiotic interaction

modulation of catalytic activity in other organism involved in symbiotic interaction

negative regulation of monocyte differentiation

negative regulation by host of symbiont molecular function

modulation by host of symbiont molecular function

complement component C1q binding

negative regulation of molecular function in other organism

negative regulation of molecular function in other organism involved in symbiotic interaction

modulation of molecular function in other organism involved in symbiotic interaction

modulation of molecular function in other organism

negative regulation by host of viral process

virion binding

negative regulation of acute inflammatory response

negative regulation of glycoprotein metabolic process

low-density lipoprotein particle binding

chaperone-mediated protein complex assembly

regulation of monocyte differentiation

negative regulation of viral entry into host cell

modulation by host of viral process

regulation of viral entry into host cell

acute-phase response

regulation of acute inflammatory response

regulation of glycoprotein metabolic process

negative regulation of myeloid leukocyte differentiation

acute inflammatory response

modification by host of symbiont morphology or physiology

negative regulation of wound healing

interaction with symbiont

negative regulation of myeloid cell differentiation

negative regulation of viral life cycle

negative regulation of response to wounding

negative regulation of viral process

negative regulation of leukocyte differentiation

modification of morphology or physiology of other organism involved in symbiotic interaction

regulation of myeloid leukocyte differentiation

unfolded protein binding

negative regulation of hemopoiesis

negative regulation of inflammatory response

regulation of wound healing

blood microparticle

regulation of viral life cycle

modification of morphology or physiology of other organism

complement activation, classical pathway

regulation of response to wounding

humoral immune response mediated by circulating immunoglobulin

carbohydrate binding

complement activation

regulation of viral process

immunoglobulin mediated immune response

negative regulation of defense response

B cell mediated immunity

negative regulation of multi-organism process

regulation of symbiosis, encompassing mutualism through parasitism

regulation of myeloid cell differentiation

protein folding

lymphocyte mediated immunity

regulation of leukocyte differentiation

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

regulation of inflammatory response

humoral immune response

negative regulation of response to external stimulus

collagen-containing extracellular matrix

negative regulation of immune system process

regulation of hemopoiesis

negative regulation of hydrolase activity

inflammatory response

adaptive immune response

activation of immune response

negative regulation of cell differentiation

calcium ion binding

regulation of defense response

leukocyte mediated immunity

innate immune response

regulation of multi-organism process

symbiotic process

negative regulation of catalytic activity

interspecies interaction between organisms

cellular protein-containing complex assembly

positive regulation of immune response

negative regulation of developmental process

defense response to other organism

identical protein binding

immune effector process

regulation of response to external stimulus

negative regulation of protein metabolic process

negative regulation of molecular function

positive regulation of immune system process

regulation of immune response

negative regulation of multicellular organismal process

regulation of hydrolase activity

response to other organism

response to external biotic stimulus

response to biotic stimulus

defense response

regulation of response to stress

protein-containing complex assembly

extracellular space

negative regulation of response to stimulus

regulation of immune system process

regulation of cell differentiation

protein-containing complex subunit organization

immune response

extracellular region

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Compound Hit

Screen	Score
Alpha-Amanitin 0.5μM R00 exp5	1.83

Most Correlated Genes in Chemogenomics

Gene	Correlation
HGC6.3	0.487

Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7894
Expression level (log2 read counts): -7.68

Expression Distribution