APOB
Gene Information
- Official Symbol: APOB
- Official Name: apolipoprotein B
- Aliases and Previous Symbols: N/A
- Entrez ID: 338
- UniProt: P04114
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA→UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| ApoB100 C |
| Vitellogenin N |
| DUF1081 |
| DUF1943 |
GO Terms
| chylomicron remnant |
| mature chylomicron |
| vesicle lumen |
| triglyceride mobilization |
| intermediate-density lipoprotein particle |
| very-low-density lipoprotein particle clearance |
| lipase binding |
| positive regulation of cholesterol storage |
| triglyceride-rich lipoprotein particle clearance |
| chylomicron remnant clearance |
| chylomicron remodeling |
| chylomicron assembly |
| response to selenium ion |
| very-low-density lipoprotein particle assembly |
| lipoprotein localization |
| lipoprotein transport |
| chylomicron |
| low-density lipoprotein particle remodeling |
| triglyceride-rich lipoprotein particle remodeling |
| regulation of cholesterol storage |
| low-density lipoprotein particle |
| lipoprotein catabolic process |
| endocytic vesicle lumen |
| positive regulation of macrophage derived foam cell differentiation |
| endosome lumen |
| cholesterol transfer activity |
| very-low-density lipoprotein particle |
| low-density lipoprotein particle receptor binding |
| positive regulation of lipid storage |
| cellular response to prostaglandin stimulus |
| high-density lipoprotein particle |
| cholesterol efflux |
| low-density lipoprotein particle clearance |
| plasma lipoprotein particle assembly |
| triglyceride catabolic process |
| smooth endoplasmic reticulum |
| plasma lipoprotein particle remodeling |
| protein-lipid complex remodeling |
| regulation of macrophage derived foam cell differentiation |
| protein-containing complex remodeling |
| endoplasmic reticulum exit site |
| protein-lipid complex assembly |
| response to prostaglandin |
| clathrin-coated endocytic vesicle membrane |
| neutral lipid catabolic process |
| acylglycerol catabolic process |
| plasma lipoprotein particle clearance |
| regulation of cholesterol biosynthetic process |
| regulation of sterol biosynthetic process |
| plasma lipoprotein particle organization |
| regulation of lipid storage |
| protein-lipid complex subunit organization |
| glycerolipid catabolic process |
| cholesterol transport |
| cellular response to fatty acid |
| regulation of cholesterol metabolic process |
| artery morphogenesis |
| sterol transport |
| sperm motility |
| flagellated sperm motility |
| regulation of plasma lipoprotein particle levels |
| regulation of alcohol biosynthetic process |
| triglyceride metabolic process |
| cholesterol homeostasis |
| sterol homeostasis |
| positive regulation of lipid localization |
| response to fatty acid |
| artery development |
| regulation of steroid biosynthetic process |
| post-embryonic development |
| lipoprotein biosynthetic process |
| lysosomal lumen |
| cilium or flagellum-dependent cell motility |
| cilium-dependent cell motility |
| acylglycerol metabolic process |
| toll-like receptor signaling pathway |
| neutral lipid metabolic process |
| retinoid metabolic process |
| phospholipid binding |
| diterpenoid metabolic process |
| regulation of steroid metabolic process |
| cholesterol metabolic process |
| lipoprotein metabolic process |
| terpenoid metabolic process |
| pattern recognition receptor signaling pathway |
| secondary alcohol metabolic process |
| lipid homeostasis |
| sterol metabolic process |
| response to estradiol |
| isoprenoid metabolic process |
| organic hydroxy compound transport |
| regulation of lipid localization |
| fertilization |
| heparin binding |
| response to carbohydrate |
| regulation of lipid biosynthetic process |
| cellular lipid catabolic process |
| cellular response to acid chemical |
| endosome membrane |
| innate immune response-activating signal transduction |
| receptor-mediated endocytosis |
| cellular response to tumor necrosis factor |
| early endosome |
| activation of innate immune response |
| steroid metabolic process |
| response to tumor necrosis factor |
| response to virus |
| lipid transport |
| lipid catabolic process |
| endoplasmic reticulum lumen |
| response to lipopolysaccharide |
| alcohol metabolic process |
| lipid localization |
| response to molecule of bacterial origin |
| positive regulation of innate immune response |
| response to acid chemical |
| positive regulation of response to biotic stimulus |
| post-translational protein modification |
| neuronal cell body |
| in utero embryonic development |
| leukocyte migration |
| glycerolipid metabolic process |
| extracellular structure organization |
| regulation of lipid metabolic process |
| blood vessel morphogenesis |
| regulation of small molecule metabolic process |
| regulation of innate immune response |
| organic hydroxy compound metabolic process |
| positive regulation of defense response |
| blood vessel development |
| positive regulation of multi-organism process |
| vasculature development |
| cardiovascular system development |
| cellular response to lipid |
| regulation of response to biotic stimulus |
| response to inorganic substance |
| spermatogenesis |
| endocytosis |
| immune response-activating signal transduction |
| male gamete generation |
| immune response-regulating signaling pathway |
| positive regulation of response to external stimulus |
| cellular response to hormone stimulus |
| activation of immune response |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| import into cell |
| protein catabolic process |
| intracellular membrane-bounded organelle |
| response to bacterium |
| gamete generation |
| regulation of defense response |
| regulation of multi-organism process |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| tube development |
| membrane organization |
| response to lipid |
| positive regulation of immune response |
| circulatory system development |
| response to hormone |
| response to organic cyclic compound |
| endoplasmic reticulum membrane |
| cellular lipid metabolic process |
| cell migration |
| positive regulation of cell differentiation |
| embryo development |
| multi-organism reproductive process |
| cellular response to cytokine stimulus |
| macromolecule catabolic process |
| cellular response to oxygen-containing compound |
| organonitrogen compound catabolic process |
| cell motility |
| localization of cell |
| regulation of response to external stimulus |
| response to cytokine |
| chemical homeostasis |
| positive regulation of immune system process |
| regulation of immune response |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| response to biotic stimulus |
| positive regulation of developmental process |
| organonitrogen compound biosynthetic process |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| regulation of response to stress |
| protein transport |
| peptide transport |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| amide transport |
| extracellular space |
| establishment of protein localization |
| homeostatic process |
| regulation of immune system process |
| cellular macromolecule biosynthetic process |
| small molecule metabolic process |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| extracellular region |
| vesicle-mediated transport |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14236
- Expression level (log2 read counts): -0.44
Expression Distribution
APOB Expression in NALM6 Cells: -0.44
