AR
Gene Information
- Official Symbol: AR
- Official Name: androgen receptor
- Aliases and Previous Symbols: N/A
- Entrez ID: 367
- UniProt: P10275
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017].
- UniProt Summary: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20980437}.
Pfam Domains GO Terms
Pfam Domains
| Hormone recep |
| zf-C4 |
| Androgen recep |
GO Terms
| RNA polymerase II general transcription initiation factor binding |
| POU domain binding |
| activation of prostate induction by androgen receptor signaling pathway |
| male somatic sex determination |
| negative regulation of integrin biosynthetic process |
| somatic sex determination |
| lateral sprouting involved in mammary gland duct morphogenesis |
| positive regulation of integrin biosynthetic process |
| tertiary branching involved in mammary gland duct morphogenesis |
| positive regulation of epithelial cell proliferation involved in prostate gland development |
| male genitalia morphogenesis |
| regulation of integrin biosynthetic process |
| androgen binding |
| male anatomical structure morphogenesis |
| regulation of prostatic bud formation |
| mammary gland branching involved in pregnancy |
| cellular response to testosterone stimulus |
| lateral sprouting from an epithelium |
| positive regulation of transcription by RNA polymerase III |
| regulation of epithelial cell proliferation involved in prostate gland development |
| Leydig cell differentiation |
| prostate gland growth |
| epithelial cell differentiation involved in prostate gland development |
| positive regulation of intracellular estrogen receptor signaling pathway |
| regulation of cell fate specification |
| seminiferous tubule development |
| positive regulation of insulin-like growth factor receptor signaling pathway |
| positive regulation of intracellular steroid hormone receptor signaling pathway |
| genitalia morphogenesis |
| regulation of plasma membrane organization |
| male sex determination |
| mammary gland lobule development |
| morphogenesis of an epithelial fold |
| mammary gland alveolus development |
| prostate gland epithelium morphogenesis |
| regulation of insulin-like growth factor receptor signaling pathway |
| sex determination |
| branching involved in mammary gland duct morphogenesis |
| male genitalia development |
| regulation of transcription by RNA polymerase III |
| prostate gland morphogenesis |
| regulation of cell fate commitment |
| steroid binding |
| mammary gland duct morphogenesis |
| positive regulation of morphogenesis of an epithelium |
| epithelial cell morphogenesis |
| animal organ formation |
| androgen receptor signaling pathway |
| regulation of animal organ formation |
| positive regulation of embryonic development |
| response to testosterone |
| regulation of intracellular estrogen receptor signaling pathway |
| prostate gland development |
| mammary gland morphogenesis |
| nuclear receptor activity |
| genitalia development |
| steroid hormone receptor activity |
| regulation of morphogenesis of a branching structure |
| mammary gland epithelium development |
| RNA polymerase II transcription factor binding |
| maternal process involved in female pregnancy |
| intracellular steroid hormone receptor signaling pathway |
| regulation of intracellular steroid hormone receptor signaling pathway |
| positive regulation of reproductive process |
| ATPase binding |
| positive regulation of animal organ morphogenesis |
| multicellular organism growth |
| beta-catenin binding |
| cellular response to ketone |
| regulation of systemic arterial blood pressure |
| regulation of protein localization to plasma membrane |
| organ growth |
| gland morphogenesis |
| negative regulation of extrinsic apoptotic signaling pathway |
| regulation of protein localization to cell periphery |
| steroid hormone mediated signaling pathway |
| negative regulation of epithelial cell proliferation |
| mammary gland development |
| regulation of embryonic development |
| branching morphogenesis of an epithelial tube |
| male gonad development |
| development of primary male sexual characteristics |
| single fertilization |
| positive regulation of NF-kappaB transcription factor activity |
| regulation of extrinsic apoptotic signaling pathway |
| male sex differentiation |
| morphogenesis of a branching epithelium |
| protein dimerization activity |
| regulation of reproductive process |
| intracellular receptor signaling pathway |
| morphogenesis of a branching structure |
| hormone-mediated signaling pathway |
| fertilization |
| transcription initiation from RNA polymerase II promoter |
| regulation of morphogenesis of an epithelium |
| female pregnancy |
| regulation of blood pressure |
| cellular response to steroid hormone stimulus |
| regulation of protein localization to membrane |
| positive regulation of epithelial cell proliferation |
| epithelial cell development |
| response to ketone |
| gonad development |
| multi-multicellular organism process |
| development of primary sexual characteristics |
| DNA-templated transcription, initiation |
| transcription regulatory region DNA binding |
| negative regulation of apoptotic signaling pathway |
| nuclear chromatin |
| regulation of animal organ morphogenesis |
| positive regulation of DNA-binding transcription factor activity |
| sex differentiation |
| protein deubiquitination |
| protein modification by small protein removal |
| epithelial tube morphogenesis |
| urogenital system development |
| response to steroid hormone |
| regulation of developmental growth |
| transcription factor binding |
| regulation of epithelial cell proliferation |
| signaling receptor binding |
| enzyme binding |
| in utero embryonic development |
| developmental growth |
| blood circulation |
| growth |
| chromatin binding |
| circulatory system process |
| regulation of apoptotic signaling pathway |
| nuclear speck |
| gland development |
| reproductive structure development |
| regulation of DNA-binding transcription factor activity |
| reproductive system development |
| morphogenesis of an epithelium |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| transcription by RNA polymerase II |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| protein complex oligomerization |
| cellular response to lipid |
| regulation of cellular protein localization |
| cellular response to organic cyclic compound |
| positive regulation of MAPK cascade |
| spermatogenesis |
| cell population proliferation |
| cell morphogenesis involved in differentiation |
| male gamete generation |
| tissue morphogenesis |
| protein-containing complex |
| cellular response to hormone stimulus |
| chordate embryonic development |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| embryo development ending in birth or egg hatching |
| RNA biosynthetic process |
| tube morphogenesis |
| developmental process involved in reproduction |
| regulation of growth |
| DNA-binding transcription factor activity |
| negative regulation of cell population proliferation |
| epithelial cell differentiation |
| gamete generation |
| negative regulation of cellular component organization |
| cell morphogenesis |
| regulation of MAPK cascade |
| cellular component morphogenesis |
| multicellular organismal reproductive process |
| sexual reproduction |
| zinc ion binding |
| multicellular organism reproduction |
| tube development |
| response to lipid |
| negative regulation of transcription by RNA polymerase II |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| response to hormone |
| positive regulation of cell population proliferation |
| regulation of cellular localization |
| response to organic cyclic compound |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| embryo development |
| protein modification by small protein conjugation or removal |
| negative regulation of cell death |
| multi-organism reproductive process |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| nucleobase-containing compound biosynthetic process |
| epithelium development |
| cell-cell signaling |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| proteolysis |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| positive regulation of signal transduction |
| RNA metabolic process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/694
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/26 |
| bone | 0/26 |
| breast | 0/30 |
| central nervous system | 0/49 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/11 |
| fibroblast | 0/1 |
| gastric | 0/14 |
| kidney | 0/18 |
| liver | 0/19 |
| lung | 0/72 |
| lymphocyte | 0/16 |
| ovary | 0/25 |
| pancreas | 0/22 |
| peripheral nervous system | 0/15 |
| plasma cell | 0/12 |
| prostate | 0/1 |
| skin | 0/20 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/28 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16151
- Expression level (log2 read counts): 1.77
Expression Distribution
AR Expression in NALM6 Cells: 1.77
