ARAP1
Gene Information
- Official Symbol: ARAP1
- Official Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 116985
- UniProt: Q96P48
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| ArfGap |
| SAM 2 |
| RA |
| RhoGAP |
| SAM 1 |
| PH |
GO Terms
| actin filament reorganization involved in cell cycle |
| type 1 angiotensin receptor binding |
| actin filament reorganization |
| positive regulation of receptor recycling |
| negative regulation of stress fiber assembly |
| regulation of receptor recycling |
| negative regulation of actin filament bundle assembly |
| positive regulation of filopodium assembly |
| positive regulation of epidermal growth factor receptor signaling pathway |
| positive regulation of ERBB signaling pathway |
| phosphatidylinositol-3,4,5-trisphosphate binding |
| regulation of filopodium assembly |
| actin cytoskeleton reorganization |
| regulation of stress fiber assembly |
| regulation of epidermal growth factor receptor signaling pathway |
| regulation of actomyosin structure organization |
| regulation of ERBB signaling pathway |
| Golgi cisterna membrane |
| regulation of actin filament bundle assembly |
| positive regulation of plasma membrane bounded cell projection assembly |
| negative regulation of supramolecular fiber organization |
| negative regulation of cytoskeleton organization |
| regulation of cell shape |
| trans-Golgi network |
| regulation of plasma membrane bounded cell projection assembly |
| regulation of cell projection assembly |
| actin filament organization |
| cytoplasmic vesicle |
| regulation of actin filament organization |
| GTPase activator activity |
| regulation of actin cytoskeleton organization |
| regulation of small GTPase mediated signal transduction |
| regulation of supramolecular fiber organization |
| negative regulation of organelle organization |
| positive regulation of cell projection organization |
| regulation of actin filament-based process |
| positive regulation of GTPase activity |
| supramolecular fiber organization |
| regulation of GTPase activity |
| regulation of cell morphogenesis |
| actin cytoskeleton organization |
| positive regulation of cellular component biogenesis |
| regulation of cytoskeleton organization |
| actin filament-based process |
| intracellular membrane-bounded organelle |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| positive regulation of hydrolase activity |
| regulation of cellular component biogenesis |
| Golgi apparatus |
| regulation of cellular component movement |
| cell cycle process |
| regulation of anatomical structure morphogenesis |
| cytoskeleton organization |
| positive regulation of cellular component organization |
| regulation of hydrolase activity |
| regulation of organelle organization |
| cell cycle |
| positive regulation of catalytic activity |
| positive regulation of signal transduction |
| positive regulation of molecular function |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8441
- Expression level (log2 read counts): 6.2
Expression Distribution
ARAP1 Expression in NALM6 Cells: 6.2
