ARHGAP29
Gene Information
- Official Symbol: ARHGAP29
- Official Name: Rho GTPase activating protein 29
- Aliases and Previous Symbols: N/A
- Entrez ID: 9411
- UniProt: Q52LW3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Rap1 is a small GTPase that, through effectors, regulates Rho GTPase signaling. These effectors- Rasip1, Radil, and the protein encoded by this gene- translocate to the cell membrane, where they form a multiprotein complex. This complex is necessary for Rap1-induced inhibition of Rho signaling. Defects in this gene may be a cause of nonsyndromic cleft lip with or without cleft palate. [provided by RefSeq, Jun 2016].
- UniProt Summary: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 11954
- Expression level (log2 read counts): 3.4
ARHGAP29 Expression in NALM6 Cells: 3.4
