ARMCX1
Gene Information
- Official Symbol: ARMCX1
- Official Name: armadillo repeat containing X-linked 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 51309
- UniProt: Q9P291
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the ALEX family of proteins and may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and two Armadillo (arm) repeats. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members, including ALEX2 and ALEX3, on the X chromosome. [provided by RefSeq, Jul 2008].
- UniProt Summary: Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1. {ECO:0000250|UniProtKB:Q9CX83}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 15917
- Expression level (log2 read counts): -5.6
ARMCX1 Expression in NALM6 Cells: -5.6
