ARNTL
Gene Information
- Official Symbol: ARNTL
- Official Name: aryl hydrocarbon receptor nuclear translocator like
- Aliases and Previous Symbols: N/A
- Entrez ID: 406
- UniProt: O00327
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| PAS |
| PAS 3 |
| HLH |
GO Terms
| oxidative stress-induced premature senescence |
| positive regulation of skeletal muscle cell differentiation |
| negative regulation of glucocorticoid receptor signaling pathway |
| maternal process involved in parturition |
| regulation of glucocorticoid receptor signaling pathway |
| stress-induced premature senescence |
| regulation of type B pancreatic cell development |
| aryl hydrocarbon receptor binding |
| chromatoid body |
| response to redox state |
| parturition |
| positive regulation of circadian rhythm |
| regulation of skeletal muscle cell differentiation |
| positive regulation of skeletal muscle tissue development |
| bHLH transcription factor binding |
| regulation of hair cycle |
| cellular senescence |
| negative regulation of intracellular steroid hormone receptor signaling pathway |
| repressing transcription factor binding |
| Hsp90 protein binding |
| regulation of cellular senescence |
| positive regulation of protein acetylation |
| negative regulation of fat cell differentiation |
| negative regulation of cold-induced thermogenesis |
| regulation of cell aging |
| regulation of skeletal muscle tissue development |
| negative regulation of TOR signaling |
| E-box binding |
| circadian regulation of gene expression |
| cell aging |
| positive regulation of striated muscle tissue development |
| positive regulation of muscle organ development |
| positive regulation of muscle tissue development |
| regulation of protein acetylation |
| transcription regulatory region sequence-specific DNA binding |
| regulation of intracellular steroid hormone receptor signaling pathway |
| protein import into nucleus |
| RNA polymerase II distal enhancer sequence-specific DNA binding |
| PML body |
| regulation of TOR signaling |
| import into nucleus |
| regulation of circadian rhythm |
| regulation of fat cell differentiation |
| regulation of striated muscle tissue development |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| circadian rhythm |
| protein import |
| regulation of epithelial cell differentiation |
| regulation of cold-induced thermogenesis |
| positive regulation of canonical Wnt signaling pathway |
| protein localization to nucleus |
| positive regulation of Wnt signaling pathway |
| regulation of insulin secretion |
| transcription factor complex |
| regulation of peptide hormone secretion |
| multi-multicellular organism process |
| cellular response to oxidative stress |
| nucleocytoplasmic transport |
| nuclear transport |
| regulation of hormone secretion |
| rhythmic process |
| aging |
| regulation of canonical Wnt signaling pathway |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| proteasomal protein catabolic process |
| regulation of Wnt signaling pathway |
| regulation of protein catabolic process |
| response to oxidative stress |
| sequence-specific DNA binding |
| establishment of protein localization to organelle |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| regulation of protein secretion |
| protein heterodimerization activity |
| regulation of peptide secretion |
| negative regulation of intracellular signal transduction |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| regulation of hormone levels |
| spermatogenesis |
| modification-dependent macromolecule catabolic process |
| male gamete generation |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| protein catabolic process |
| intracellular membrane-bounded organelle |
| gamete generation |
| regulation of protein transport |
| negative regulation of cell differentiation |
| regulation of cellular response to stress |
| protein localization to organelle |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of secretion |
| regulation of neurogenesis |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| cellular macromolecule catabolic process |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| multi-organism reproductive process |
| regulation of catabolic process |
| intracellular protein transport |
| regulation of protein localization |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| proteolysis |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| protein transport |
| negative regulation of cellular biosynthetic process |
| intracellular transport |
| generation of neurons |
| peptide transport |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| nitrogen compound transport |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13168
- Expression level (log2 read counts): 4.09
Expression Distribution
ARNTL Expression in NALM6 Cells: 4.09
