ASB9
Gene Information
- Official Symbol: ASB9
- Official Name: ankyrin repeat and SOCS box containing 9
- Aliases and Previous Symbols: N/A
- Entrez ID: 140462
- UniProt: Q96DX5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein family. Members of this family can interact with the elongin B-C adapter complex via their SOCS box domain and further complex with the cullin and ring box proteins to form E3 ubiquitin ligase complexes. They may function to mediate the substrate-recognition of the E3 ubiquitin ligases. A transcribed pseudogene of this gene has been identified on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009].
- UniProt Summary: Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A. {ECO:0000269|PubMed:22418839}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 6179
- Expression level (log2 read counts): 0.36
ASB9 Expression in NALM6 Cells: 0.36
