ASCC1
Gene Information
- Official Symbol: ASCC1
- Official Name: activating signal cointegrator 1 complex subunit 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 51008
- UniProt: Q8N9N2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
- UniProt Summary: Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction. {ECO:0000269|PubMed:19074642, ECO:0000269|PubMed:26924529}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8990
- Expression level (log2 read counts): 5.52
ASCC1 Expression in NALM6 Cells: 5.52
