ATP11C
Gene Information
- Official Symbol: ATP11C
- Official Name: ATPase phospholipid transporting 11C
- Aliases and Previous Symbols: N/A
- Entrez ID: 286410
- UniProt: Q8NB49
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| E1-E2 ATPase |
| HAD |
| Hydrolase |
GO Terms
| pre-B cell differentiation |
| immature B cell differentiation |
| positive regulation of B cell differentiation |
| ATPase-coupled intramembrane lipid transporter activity |
| regulation of B cell differentiation |
| phospholipid translocation |
| lipid translocation |
| regulation of membrane lipid distribution |
| phospholipid transport |
| positive regulation of lymphocyte differentiation |
| B cell differentiation |
| recycling endosome |
| organophosphate ester transport |
| positive regulation of leukocyte differentiation |
| B cell activation |
| positive regulation of B cell activation |
| regulation of lymphocyte differentiation |
| trans-Golgi network |
| positive regulation of hemopoiesis |
| regulation of B cell activation |
| magnesium ion binding |
| lymphocyte differentiation |
| regulation of leukocyte differentiation |
| lipid transport |
| lysosomal membrane |
| lipid localization |
| leukocyte differentiation |
| positive regulation of lymphocyte activation |
| lymphocyte activation |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| regulation of hemopoiesis |
| organic anion transport |
| regulation of lymphocyte activation |
| hemopoiesis |
| anion transport |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| regulation of cell activation |
| immune system development |
| membrane organization |
| leukocyte activation |
| endoplasmic reticulum membrane |
| ion transmembrane transport |
| positive regulation of cell differentiation |
| endoplasmic reticulum |
| cell activation |
| positive regulation of immune system process |
| transmembrane transport |
| positive regulation of developmental process |
| ion transport |
| ATP binding |
| regulation of immune system process |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Azithromycin 100μM R08 exp452 | 1.76 |
| LLY-283 2.6μM R06 exp290 | 1.96 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/694
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/26 |
| bone | 0/26 |
| breast | 0/30 |
| central nervous system | 0/49 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/11 |
| fibroblast | 0/1 |
| gastric | 0/14 |
| kidney | 0/18 |
| liver | 0/19 |
| lung | 0/72 |
| lymphocyte | 0/16 |
| ovary | 0/25 |
| pancreas | 0/22 |
| peripheral nervous system | 0/15 |
| plasma cell | 0/12 |
| prostate | 0/1 |
| skin | 0/20 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/28 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18690
- Expression level (log2 read counts): 6.73
Expression Distribution
ATP11C Expression in NALM6 Cells: 6.73
