BAMBI
Gene Information
- Official Symbol: BAMBI
- Official Name: BMP and activin membrane bound inhibitor
- Aliases and Previous Symbols: N/A
- Entrez ID: 25805
- UniProt: Q13145
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Negatively regulates TGF-beta signaling.
Pfam Domains GO Terms
Pfam Domains
| BAMBI |
GO Terms
| type II transforming growth factor beta receptor binding |
| frizzled binding |
| positive regulation of epithelial to mesenchymal transition |
| negative regulation of transforming growth factor beta receptor signaling pathway |
| negative regulation of cellular response to transforming growth factor beta stimulus |
| regulation of epithelial to mesenchymal transition |
| positive regulation of protein binding |
| transforming growth factor beta receptor signaling pathway |
| regulation of transforming growth factor beta receptor signaling pathway |
| regulation of cellular response to transforming growth factor beta stimulus |
| negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| positive regulation of canonical Wnt signaling pathway |
| negative regulation of cellular response to growth factor stimulus |
| regulation of cell shape |
| cellular response to transforming growth factor beta stimulus |
| response to transforming growth factor beta |
| positive regulation of Wnt signaling pathway |
| positive regulation of binding |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of protein binding |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of cellular response to growth factor stimulus |
| regulation of canonical Wnt signaling pathway |
| regulation of Wnt signaling pathway |
| regulation of binding |
| regulation of cell morphogenesis |
| cellular response to growth factor stimulus |
| response to growth factor |
| enzyme linked receptor protein signaling pathway |
| positive regulation of cell population proliferation |
| cell migration |
| positive regulation of cell differentiation |
| regulation of anatomical structure morphogenesis |
| cell motility |
| localization of cell |
| cellular response to endogenous stimulus |
| negative regulation of signal transduction |
| locomotion |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| response to endogenous stimulus |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 5/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 2/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 2/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 1/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9653
- Expression level (log2 read counts): 0.27
Expression Distribution
BAMBI Expression in NALM6 Cells: 0.27
