BAZ1A
Gene Information
- Official Symbol: BAZ1A
- Official Name: bromodomain adjacent to zinc finger domain 1A
- Aliases and Previous Symbols: N/A
- Entrez ID: 11177
- UniProt: Q9NRL2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end- positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3526
- Expression level (log2 read counts): 8.01
BAZ1A Expression in NALM6 Cells: 8.01
